DivIDE:
Spindle Structure
From protein to Architecture
September 25-28, 2023
The sentence "What I cannot create, I do not understand" attributed to physicist Richard Feynman, summarizes the spirit of the DivIDE Conference, which wants to push the ambition of modern-day structural biology to the limit of what is currently possible.
The focus of this conference is the structural and functional understanding of the spindle. The microtubule cytoskeleton is essential for a wide variety of cellular functions, among which we can find chromosome segregation and cell division. These processes can be modulated by various strategies that can lead to human diseases, including but not limited to cancer. In recent years, cell and molecular biology increasingly boost our knowledge of protein functions involved in spindle assembly and chromosome segregation. This further spikes an increasing interest and need for structural biology and mathematical modeling that can give us insights into the structural organization of the spindle.
The progressive shift towards these felids has created the need for a strong meeting that brings together researchers from different disciplines interested in the structural understanding of the spindle and microtubules. This role has been played by the DivIDE conference, which was initiated in 2018. DivIDE meeting brings together scientists working on quantitative imaging and theoretical modeling of the spindle. This year we will also expand our meeting by focusing on new ML developments that can boost high-throughput data collection and analysis.
Following the tradition from our previous meeting, this conference will feature inspiring keynote lectures, opportunities for early-career researchers to present their research in short or flash talks selected from the submitted abstracts, poster session, and networking activities.
This session will be devoted to protein-mediated
microtubule structure organization in the spindle.
More coming soon!
Mitotic and Meiotic spindles are organized by thousands
of microtubules. Nowadays, the primary focus is put on
studying the interplay of individual proteins and their
functional and structural role in organizing microtubules.
However, to understand how these proteins play a role
in the formation of the microtubule network, it is needed
to dissect a high-order organization of all MTs in the
spindle.
This session will be devoted to the current progress
in understanding microtubule high-order organization
in the spindle.
More coming soon!
More and more often progress in science drives technology
development. Structural study of microtubule organization
in vitro and in vivo are not different from
this role.
This session will be devoted to new and novel
analytic approaches that can brother our understanding
of the spindle.
More coming soon!
Submit your abstract (max 400 words) for a 15-minute talk and/or poster presentation on the registration form. With over 30 speaking opportunities available, this is a great chance to showcase your research and ideas.
Important deadlines:
| Time | Mon 25 | Tue 26 | Wed 27 | Thu 28 |
|---|---|---|---|---|
| 9:00 AM |
Assembly and function of the kinetochore corona. |
Chromosome size alters kinetochore attachment stability and alignment order in mammalian mitosis |
Understanding the regulation of microtubule dynamics by KLP-19 (Kif4a) in the spindle midzone |
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TBD |
TBD |
TBD |
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| 10:00 AM | ||||
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TBD |
TBD |
TBD |
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| 11:00 AM | ||||
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TBD |
TBD |
TBD |
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| 12:00 AM | ||||
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TBD |
TBD |
TBD |
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| 1:00 PM | ||||
| 2:00 PM |
TBD |
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| 3:00 PM |
KIF2A is a minus end depolymerase and drives flux-like treadmilling of γTuRC-uncapped microtubules |
Lessons from 3D reconstruction of mitotic spindle architecture |
Structural basis of temperature-adaptation in microtubule dynamics |
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TBD |
TBD |
TBD |
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| 4:00 PM |
TBD |
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Biophysics of spindles in human tissue culture cells |
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TBD |
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| 5:00 PM | ||||
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TBD |
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TBD |
TBD |
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| 6:00 PM | ||||
| 7:00 PM | ||||
2nd Divide conference will be held in the Centre for Genomic Regulation (CRG) | Barcelona, Spain