DivIDE:
Spindle Structure
From protein to Architecture

September 25-28, 2023

About conference

The sentence "What I cannot create, I do not understand" attributed to physicist Richard Feynman, summarizes the spirit of the DivIDE Conference, which wants to push the ambition of modern-day structural biology to the limit of what is currently possible.

The focus of this conference is the structural and functional understanding of the spindle. The microtubule cytoskeleton is essential for a wide variety of cellular functions, among which we can find chromosome segregation and cell division. These processes can be modulated by various strategies that can lead to human diseases, including but not limited to cancer. In recent years, cell and molecular biology increasingly boost our knowledge of protein functions involved in spindle assembly and chromosome segregation. This further spikes an increasing interest and need for structural biology and mathematical modeling that can give us insights into the structural organization of the spindle.

The progressive shift towards these felids has created the need for a strong meeting that brings together researchers from different disciplines interested in the structural understanding of the spindle and microtubules. This role has been played by the DivIDE conference, which was initiated in 2018. DivIDE meeting brings together scientists working on quantitative imaging and theoretical modeling of the spindle. This year we will also expand our meeting by focusing on new ML developments that can boost high-throughput data collection and analysis.

Following the tradition from our previous meeting, this conference will feature inspiring keynote lectures, opportunities for early-career researchers to present their research in short or flash talks selected from the submitted abstracts, poster session, and networking activities.

Conference Main Sessions

Protein Mediated Spindle Structure

This session will be devoted to protein-mediated microtubule structure organization in the spindle.

More coming soon!

Dissecting the Higher Order Architecture of the Spindle

Mitotic and Meiotic spindles are organized by thousands of microtubules. Nowadays, the primary focus is put on studying the interplay of individual proteins and their functional and structural role in organizing microtubules. However, to understand how these proteins play a role in the formation of the microtubule network, it is needed to dissect a high-order organization of all MTs in the spindle.
This session will be devoted to the current progress in understanding microtubule high-order organization in the spindle.

More coming soon!

Novel Approaches for Studying Spindle Structure

More and more often progress in science drives technology development. Structural study of microtubule organization in vitro and in vivo are not different from this role.
This session will be devoted to new and novel analytic approaches that can brother our understanding of the spindle.

More coming soon!

Keynote Speaker

  • Daniel Needleman
    Gordon McKay Professor of Applied Physics
    Professor of Molecular and Cellular Biology
    Harvard University
    Center for Computational Biology
    Flatiron Institute

Invited Speakers

  • Sophie Dumont
    University of California
    San Francisco, USA

  • Thomas Müller-Reichert
    Faculty of Medicine Carl Gustav Carus
    Dresden, Germany

  • Andrea Musacchio
    Max Planck Institute of Molecular Physiology
    Dortmund, Germany

  • Thomas Surrey
    Centre for Genomic Regulation (CRG)
    Barcelona, Spain

  • Simone Reber
    Humboldt-Universität zu Berlin
    Berlin, Germany

  • Stefanie Redemann
    University of Virginia
    Charlottesville, USA

Registration

Submit your abstract (max 400 words) for a 15-minute talk and/or poster presentation on the registration form. With over 30 speaking opportunities available, this is a great chance to showcase your research and ideas.

Important deadlines:

  • Early registration deadline - till 31.03.2023
  • Late registration deadline - till 10.07.2023
  • Notification of talks/poster acceptance — by 17.07.2023

Late Registration

Closed
  • 350€ Academia
  • 100€ Virtual only
Closed

Virtual Registration

till 01.09.2023
  • 100€ Virtual only
Closed

Program

Time Mon 25 Tue 26 Wed 27 Thu 28
9:00 AM

Assembly and function of the kinetochore corona.

Chromosome size alters kinetochore attachment stability and alignment order in mammalian mitosis

Understanding the regulation of microtubule dynamics by KLP-19 (Kif4a) in the spindle midzone

TBD

TBD

TBD

10:00 AM

TBD

TBD

TBD

11:00 AM

TBD

TBD

TBD

12:00 AM

TBD

TBD

TBD

1:00 PM
2:00 PM

TBD

3:00 PM

KIF2A is a minus end depolymerase and drives flux-like treadmilling of γTuRC-uncapped microtubules

Lessons from 3D reconstruction of mitotic spindle architecture

Structural basis of temperature-adaptation in microtubule dynamics

TBD

TBD

TBD

4:00 PM

TBD

Biophysics of spindles in human tissue culture cells

TBD

5:00 PM

TBD

TBD

TBD

6:00 PM
7:00 PM

Venue

2nd Divide conference will be held in the Centre for Genomic Regulation (CRG) | Barcelona, Spain

Organizers

  • Robert Kiewisz
    Simons Machine Learning Center
    NY, USA
    Centro Nacional de Biotecnologia
    Madrid, Spain

  • Kseniya Ustinova
    Centre for Genomic Regulation (CRG)
    Barcelona, Spain


  • Isabelle Vernos
    Centre for Genomic Regulation (CRG)
    Barcelona, Spain


  • Silvia Speroni
    Centre for Genomic Regulation (CRG)
    Barcelona, Spain


Scientific Board

  • Tristan Bepler
    Simons Machine Learning Center
    NY, USA

  • Felix Ruhnow
    Centre for Genomic Regulation
    Barcelona, Spain

Institutions